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4-ACO-DMT

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4-ACO-DMT, O-Acetylpsilocin is a synthetically produced psychoactive drug and has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies, as they are both believed to be prodrugs of psilocin.
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Description

4-Acetoxy-N,N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, and psilacetin) is a novel psychedelic substance of the tryptamine class.4-aco-dmt texas,4-aco-dmt wiki,4-aco-dmt vs 5-meo-dmt,4-aco-dmt vendor usa

It is a structural analog of psilocybin, the active ingredient in psilocybin mushrooms (magic mushrooms). Like psilocybin, it is thought to produce its effects primarily by binding to serotonin receptors in the brain; however, the precise mechanism is not fully understood.

The synthesis of 4-AcO-DMT was first reported in 1963 by Albert Hofmann and Franz Troxler as part of an investigation into psilocin analogs.

However, its pharmacology and subjective effects were not explored. A paper authored by David E. Nichols in 1999 proposed it as a potentially useful alternative to psilocybin for pharmacological research due to lower cost of synthesis.

 Reports of recreational use began to surface shortly after its appearance on the online research chemical market in the 2010s.

Subjective effects are reported to be nearly identical to those of psilocybin mushrooms and include geometric visual hallucinations, time distortion, enhanced introspection, euphoria, and ego loss.

It is theorized to act as a prodrug to psilocin in a similar manner as psilocybin, which may account for this similarity.

It’s classical psychedelic effects and favorable tolerability profile has led it to become popular among novel psychoactive substance users who seek mystical or entheogenic experiences.

Very little data exists on the pharmacology, metabolism, and toxicity of 4-AcO-DMT. While it is believed to have a favorable safety profile similar to that of psilocybin mushrooms (which are known to be physiologically non-toxic) there is currently no data to support this claim. It is highly advised to use harm reduction practices if using this substance.4-aco-dmt texas,4-aco-dmt wiki,4-aco-dmt vs 5-meo-dmt,4-aco-dmt vendor usa

The compound has been suggested by David Nichols to be a potentially useful alternative to psilocybin for pharmacological studies as they are both believed to be prodrugs of psilocin.

Its structural similarities to psilocin and psilocybin results in an identical subjective effect profile and the three compounds can be said to feel indistinguishable from each other.

This allows it to function as a perfect substitute for psilocybin mushrooms.

It is and several other esters of psilocin were originally patented on January 16, 1963 by Sandoz Ltd.
via Albert Hofmann & Franz Troxler.

Despite this fact, 4-AcO-DMT remains a psychedelic with a limited history of use prior to its release as a grey area compound on the online research chemical market.4-aco-dmt wiki

It ‘s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.4-aco-dmt texas.

Pharmacology

The psychedelic effects of 4-AcO-DMT are believed to come from its activity as a partial agonist for the 5-HT2A receptor.

However, the role of these interactions and how they result in the psychedelic experience is the subject of ongoing scientific investigation.

In the body, 4-AcO-DMT is suspected to be deacetylated into psilocin during first pass metabolism, by the acidic conditions in the stomach, and as it passes through the liver.

Synonyms
  • ​Acetylpsilocin
  • 4-acetoxy-N,N-Dimethyltryptamine
  • 4-AcO DMT
Technical Information
Formal Name
3-[2-(dimethylamino)ethyl]-1H-indol-4-ol-4-acetate, monohydrochloride
Molecular Formula
C14H18N2O2 • HCl
Formula Weight
282.8
Purity
≥90%
Formulation
A solution in acetonitrile
λmax
219, 277 nm
SMILES
CN(C)CCC1=CNC2=CC=CC(OC(C)=O)=C21.Cl
InChi Code
InChI=1S/C14H18N2O2.ClH/c1-10(17)18-13-6-4-5-12-14(13)11(9-15-12)7-8-16(2)3;/h4-6,9,15H,7-8H2,1-3H3;1H
InChi Key
OEPCTLAWMZJUIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years

Additional information

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